STX8
Sign in to saveAlso known as CARB, syntaxin 8
Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.
Gene data
STX8- Name
- syntaxin 8
- Type
- protein-coding
- Position
- 9,250,149–9,576,591 (−)
- Aliases
- CARB
- Ensembl
- ENSG00000170310
- RefSeq RNA
- NM_004853.3, NR_033656.2, XM_011524079.2, XM_054317836.1, XM_054317837.1
- RefSeq protein
- NP_004844.1, XP_011522381.1, XP_054173811.1, XP_054173812.1
The gene is a member of the syntaxin family. The encoded protein is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. A related pseudogene has been identified on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
syntaxin 8
- Symbol
- STX8
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:9,250,149-9,576,591
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein STX8 PDB 1gl2.png
Show 7 more facts
- HomoloGene ID
- 37973
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9482
- genomic end
- 9479908
- genomic start
- 9153788
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- Interactions
- References
- Further reading
Syntaxin-8 is a protein that in humans is encoded by the STX8 gene. Syntaxin 8 directly interacts with HECTd3 and has similar subcellular localization. The protein has been shown to form the SNARE complex with syntaxin 7, vti1b and endobrevin. These function as the machinery for the homotypic fusion of late endosomes.
== Interactions ==
Excerpted from Wikipedia’s “STX8” article, available under the CC BY-SA 4.0 licence.