TBCE
Sign in to saveAlso known as HRD, KCS, KCS1, pac2, tubulin folding cofactor E, PEAMO
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.
Gene data
TBCE- Name
- tubulin folding cofactor E
- Type
- protein-coding
- Position
- 235,367,360–235,452,443 (+)
- Aliases
- HRD, KCS, KCS1, PEAMO, pac2
- Ensembl
- ENSG00000284770
- RefSeq RNA
- NM_001079515.3, NM_001287801.2, NM_001287802.2, NM_003193.5
- RefSeq protein
- NP_001072983.1, NP_001274730.1, NP_001274731.1, NP_003184.1
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Cellular component
via MyGene.info
Wikidata facts
Show 3 more facts
- HomoloGene ID
- 37744
- exact match
- identifiers.org/ncbigene/6905
- cytogenetic location
- 1q42.3
Sources (3)
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Article
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- Further reading
Tubulin-specific chaperone E is a protein that in humans is encoded by the TBCE gene.
Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene.