TBCA
Sign in to saveAlso known as tubulin folding cofactor A
Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.
In the Vinony graph
Within Vinony's link graph, TBCA is referenced by 2 other articles, and connects out to PubMed, human chromosome 5 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 5.
Its subject is documented across 7 Wikipedia language editions.
Gene data
TBCA- Name
- tubulin folding cofactor A
- Type
- protein-coding
- Position
- 77,690,172–77,868,780 (−)
- Ensembl
- ENSG00000171530
- RefSeq RNA
- NM_001297738.2, NM_001297740.2, NM_004607.3
- RefSeq protein
- NP_001284667.1, NP_001284669.1, NP_004598.1
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tubulin folding cofactor A
- Symbol
- TBCA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:77,690,172-77,868,780
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TBCA PDB 1h7c.png
Show 7 more facts
- HomoloGene ID
- 3388
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/6902
- genomic end
- 77164604
- genomic start
- 76986991
- chromosome
- human chromosome 5
- cytogenetic location
- 5q14.1
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Tubulin-specific chaperone A is a protein that in humans is encoded by the TBCA gene.
The product of this gene is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. This gene encodes chaperonin cofactor A.
Excerpted from Wikipedia’s “TBCA” article, available under the CC BY-SA 4.0 licence.