Structure via PubChem · Public domain (PubChem)
terguride
Sign in to saveAlso known as dironyl
Terguride (, ), sold under the brand name Teluron, is a serotonin receptor antagonist and dopamine receptor agonist of the ergoline family. It is approved for and used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) in Japan. Terguride is taken by mouth.
Chemical data
- Formula
- C20H28N4O
- Molecular weight
- 340.5 g/mol
- IUPAC name
- 3-[(6aR,9S,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinolin-9-yl]-1,1-diethylurea
- SMILES
- CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)C
- InChIKey
- JOAHPSVPXZTVEP-YXJHDRRASA-N
- XLogP
- 2.5
- Polar surface area
- 51.4 Ų
- H-bond donors
- 2
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
215 papers- Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats.The European respiratory journal · 2011
- Blocking properties of terguride at the 5-HT(2) receptor subtypes mediating cardiovascular responses in the rat.Canadian journal of physiology and pharmacology · 2020
- Antiserotonergic properties of terguride in blood vessels, platelets, and valvular interstitial cells.The Journal of pharmacology and experimental therapeutics · 2012
- Terguride for dyskinesias.Neurology · 1993
- Terguride as a new anti-hyperprolactinemic agent: characterization in rats and dogs in comparison with bromocriptine.Japanese journal of pharmacology · 1993
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 340.226312
- Has use
- medication
Show 4 more facts
- chemical formula
- C₂₀H₂₈N₄O
- isomeric SMILES
- CCN(CC)C(=O)N[C@H]1C[C@H]2[C@@H](CC3=CNC4=CC=CC2=C34)N(C1)C
- canonical SMILES
- CCN(CC)C(=O)NC1CC2C(CC3=CNC4=CC=CC2=C34)N(C1)C
- subject has role
- dopamine agonist
Sources (2)
via Wikidata · CC0
~3 min read
Encyclopedic overview
5 sectionsContents
- Pharmacology
- Pharmacodynamics
- Research
- See also
- References
Terguride (, ), sold under the brand name Teluron, is a serotonin receptor antagonist and dopamine receptor agonist of the ergoline family. It is approved for and used as a prolactin inhibitor in the treatment of hyperprolactinemia (high prolactin levels) in Japan. Terguride is taken by mouth.
==Pharmacology==
Excerpted from Wikipedia’s “terguride” article, available under the CC BY-SA 4.0 licence.
Available in 9 languages
via Wikidata sitelinks · CC0