TGIF1

Name

TGFB induced factor homeobox 1

Type

protein-coding

Position

3,411,608–3,459,978 (+)

Aliases

HPE4, TGIF

Ensembl

ENSG00000177426

RefSeq RNA

NM_001278682.2, NM_001278684.2, NM_001278686.3, NM_001374396.1, NM_001374397.1

RefSeq protein

NP_001265611.1, NP_001265613.1, NP_001265615.1, NP_001361325.1, NP_001361326.1

The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013].

via MyGene.info

Gene · Ensembl

TGFB induced factor homeobox 1

Symbol

TGIF1

Biotype

Protein coding

Organism

Homo sapiens

Location

18:3,411,608-3,459,978

Strand

Forward (+)

Assembly

GRCh38