tibolone
Sign in to saveAlso known as Livial, 17-hydroxy-7alpha-methyl-19-nor-17alpha-pregn-5(10)-en-20-yn-3-one, tibolonum, tibolona, Org OD14, tibilone, Tibofem
Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken by mouth.
Key facts
- Drug.legal_AU
- S4
- Drug.Verifiedfields
- verified
- Drug.Watchedfields
- verified
- Drug.verifiedrevid
- 470610138
- Drug.image
- Tibolone.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 225
- Drug.image2
- Tibolone molecule ball.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 235
- Drug.tradename
- Livial, Tibella, Tibofem, others
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Progestogen; Progestin; Estrogen; Androgen; Anabolic steroid
- Drug.ATC_prefix
- G03
- Drug.ATC_suffix
- CX01
- Drug.legal_CA
- Schedule IV
- Drug.legal_UK
- POM
via Wikipedia infobox
Research
1,287 papers- Tibolone and Breast Tissue: a Review.Reproductive sciences (Thousand Oaks, Calif.) · 2023
- Repurposing of Tibolone in Alzheimer's Disease.Biomolecules · 2023
- Tibolone as Hormonal Therapy and Neuroprotective Agent.Trends in endocrinology and metabolism: TEM · 2020
- Tibolone: a review.Maturitas · 1998
- Tibolone and breast cancer.Postgraduate medical journal · 2006
via PubMed
Wikidata facts
- Mass
- 312.208930136
Show 6 more facts
- chemical formula
- C₂₁H₂₈O₂
- canonical SMILES
- CC1CC2=C(CCC(=O)C2)C3C1C4CCC(C4(CC3)C)(C#C)O
- Commons category
- Tibolone
- isomeric SMILES
- C[C@@H]1CC2=C(CCC(=O)C2)[C@H]3CC[C@@]4(C)[C@@H](CC[C@@]4(O)C#C)[C@H]13
- NCI Thesaurus ID
- C66955
- defined daily dose
- 2.5
via Wikidata · CC0
~17 min read
Article
20 sectionsContents
- Medical uses
- Available forms
- Side effects
- Pharmacology
- Pharmacodynamics
- Estrogenic activity
- Progestogenic activity
- Androgenic activity
- Other activities
- Pharmacokinetics
- Chemistry
- Synthesis
- History
- Society and culture
- Generic names
- Brand names
- Availability
- Legal status
- References
- Further reading
Tibolone, sold under the brand name Livial among others, is a medication which is used in menopausal hormone therapy and in the treatment of postmenopausal osteoporosis and endometriosis. The medication is available alone and is not formulated or used in combination with other medications. It is taken by mouth.
Side effects of tibolone include acne and increased hair growth among others. Tibolone is a synthetic steroid with weak estrogenic, progestogenic, and androgenic activity, and hence is an agonist of the estrogen, progesterone, and androgen receptors. It is a prodrug of several metabolites. The estrogenic effects of tibolone may show tissue selectivity in their distribution.