TM4SF5
Sign in to saveAlso known as transmembrane 4 L six family member 5
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.
In the Vinony graph
Vinony's link graph records 2 inbound references to TM4SF5, and connects out to PubMed, human chromosome 17 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 17.
Vinony links it to 5 Wikipedia language editions.
Gene data
TM4SF5- Name
- transmembrane 4 L six family member 5
- Type
- protein-coding
- Position
- 4,771,835–4,783,220 (+)
- Ensembl
- ENSG00000142484
- RefSeq RNA
- NM_003963.3
- RefSeq protein
- NP_003954.2
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
transmembrane 4 L six family member 5
- Symbol
- TM4SF5
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 17:4,771,835-4,783,220
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 2947
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/9032
- genomic end
- 4686506
- genomic start
- 4675179
- chromosome
- human chromosome 17
- cytogenetic location
- 17p13.2
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is highly similar in sequence and structure to transmembrane 4 superfamily member 1. It may play a role in cell proliferation, and overexpression of this protein may be associated with the uncontrolled growth of tumour cells.
Excerpted from Wikipedia’s “TM4SF5” article, available under the CC BY-SA 4.0 licence.