TPM4
Sign in to saveAlso known as HEL-S-108, tropomyosin 4
Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.
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Vinony's link graph records 272 inbound references to TPM4, and connects out to hair keratin, PubMed and human chromosome 19.
It is catalogued under the topic Genes on human chromosome 19.
Vinony links it to 5 Wikipedia language editions.
Gene data
TPM4- Name
- tropomyosin 4
- Type
- protein-coding
- Position
- 16,067,021–16,103,011 (+)
- Aliases
- BDPLT25, HEL-S-108
- Ensembl
- ENSG00000167460
- RefSeq RNA
- NM_001145160.2, NM_001367836.1, NM_001367837.2, NM_001367838.1, NM_003290.3
- RefSeq protein
- NP_001138632.1, NP_001354765.1, NP_001354766.1, NP_001354767.1, NP_003281.1
This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2009].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
tropomyosin 4
- Symbol
- TPM4
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:16,067,021-16,103,011
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 7 more facts
- HomoloGene ID
- 100849
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/7171
- genomic end
- 16103002
- genomic start
- 16177831
- chromosome
- human chromosome 19
- cytogenetic location
- 19p13.12-p13.11
Sources (4)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Tropomyosin alpha-4 chain is a protein that in humans is encoded by the TPM4 gene.
==References==
Excerpted from Wikipedia’s “TPM4” article, available under the CC BY-SA 4.0 licence.