TNFSF18
Sign in to saveAlso known as AITRL, GITRL, TL6, hGITRL, TNLG2A, tumor necrosis factor superfamily member 18, TNF superfamily member 18
Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.
Gene data
TNFSF18- Name
- TNF superfamily member 18
- Type
- protein-coding
- Position
- 173,039,202–173,050,941 (−)
- Aliases
- AITRL, GITRL, TL6, TNLG2A, hGITRL
- Ensembl
- ENSG00000120337
- RefSeq RNA
- NM_005092.4
- RefSeq protein
- NP_005083.3
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
TNF superfamily member 18
- Symbol
- TNFSF18
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:173,039,202-173,050,941
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein TNFSF18 PDB 2Q1M.png
Show 8 more facts
- HomoloGene ID
- 3732
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/8995
- genomic end
- 173050941
- genomic start
- 173039202
- chromosome
- human chromosome 1
- cytogenetic location
- 1q25.1
- expressed in
- duodenum
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- References
- Further reading
Tumor necrosis factor ligand superfamily member 18 is a protein that in humans is encoded by the TNFSF18 gene.
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells.
Excerpted from Wikipedia’s “TNFSF18” article, available under the CC BY-SA 4.0 licence.