TOP2B

Name

DNA topoisomerase II beta

Type

protein-coding

Position

25,597,978–25,664,973 (−)

Aliases

BILU, TOPIIB, top2beta

Ensembl

ENSG00000077097

RefSeq RNA

NM_001068.3, NM_001330700.2, XM_011534057.4, XM_047448821.1, XM_047448822.1

RefSeq protein

NP_001059.2, NP_001317629.1, XP_011532359.1, XP_047304777.1, XP_047304778.1

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016].

via MyGene.info

Gene · Ensembl

DNA topoisomerase II beta

Symbol

TOP2B

Biotype

Protein coding

Organism

Homo sapiens

Location

3:25,597,978-25,664,973

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Image

4j3ncartoon.png

via Wikidata · CC0