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triclabendazole
Sign in to saveAlso known as EGA230
Triclabendazole, sold under the brand name Egaten among others, is a medication used to treat fascioliasis and paragonimiasis. It is very effective for both conditions. Treatment in hospital may be required. It is taken by mouth with typically one or two doses being required.
Chemical data
- Formula
- C14H9Cl3N2OS
- Molecular weight
- 359.7 g/mol
- IUPAC name
- 6-chloro-5-(2,3-dichlorophenoxy)-2-methylsulfanyl-1H-benzimidazole
- SMILES
- CSC1=NC2=CC(=C(C=C2N1)Cl)OC3=C(C(=CC=C3)Cl)Cl
- InChIKey
- NQPDXQQQCQDHHW-UHFFFAOYSA-N
- XLogP
- 5.7
- Polar surface area
- 63.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Research
797 papers- Triclabendazole in the treatment of human fascioliasis: a review.Transactions of the Royal Society of Tropical Medicine and Hygiene · 2019
- Understanding triclabendazole resistance.Experimental and molecular pathology · 2007
- Triclabendazole for the treatment of human fascioliasis and the threat of treatment failures.Expert review of anti-infective therapy · 2021
- Triclabendazole for the treatment of fascioliasis and paragonimiasis.Expert opinion on investigational drugs · 2005
- Triclabendazole for the treatment of fascioliasis.Drugs of today (Barcelona, Spain : 1998) · 2019
via PubMed
~2 min read
Encyclopedic overview
4 sectionsContents
- Chemistry
- History
- References
- Further reading
Triclabendazole, sold under the brand name Egaten among others, is a medication used to treat fascioliasis and paragonimiasis. It is very effective for both conditions. Treatment in hospital may be required. It is taken by mouth with typically one or two doses being required.
Side effects are generally few, but can include abdominal pain and headaches. Biliary colic may occur due to dying worms. While no harm has been found with use during pregnancy, triclabendazole has not been studied well in this population. It is a member of the benzimidazole family of medications for worms.
Excerpted from Wikipedia’s “triclabendazole” article, available under the CC BY-SA 4.0 licence.