oxantel
Sign in to saveOxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms. It has also been shown to inhibit fumarate reductase in some pathogenic bacteria.
Research
110 papers- Preclinical and Clinical Characteristics of the Trichuricidal Drug Oxantel Pamoate and Clinical Development Plans: A Review.Drugs · 2021
- Oxantel pamoate-albendazole for Trichuris trichiura infection.The New England journal of medicine · 2014
- Functional Characterization of the Oxantel-Sensitive Acetylcholine Receptor from Trichuris muris.Pharmaceuticals (Basel, Switzerland) · 2021
- The narrow-spectrum anthelmintic oxantel is a potent agonist of a novel acetylcholine receptor subtype in whipworms.PLoS pathogens · 2021
- Oxantel pamoate and deworming programmes.The Lancet. Infectious diseases · 2016
via PubMed
Wikidata facts
- Mass
- 216.126
Show 4 more facts
- isomeric SMILES
- CN1CCCN=C1/C=C/c1cccc(O)c1
- chemical formula
- C₁₃H₁₆N₂O
- canonical SMILES
- CN1CCCN=C1C=CC2=CC(=CC=C2)O
- NCI Thesaurus ID
- C96694
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Article
1 sectionsContents
- References
Oxantel is an anthelmintic. It has typically been used in human and animal medicine as a treatment for intestinal worms. It has also been shown to inhibit fumarate reductase in some pathogenic bacteria.
Similarly to pyrantel, oxantel depolarises the neurons of gastrointestinal parasites 100x more than acetylcholine, causing sustained muscular contraction, causing the parasites to die by spastic paralysis. This anthelmintic is commonly used to treat domestic animals as well as livestock, and resistance has been reported in both groups of animals.
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