triiodothyronine
Also known as 3,5,3'-triodo-L-thyronine, Cytomel®, liothyronine sodium, T3, 3,3',5-triiodo-L-thyronine, O-(4-hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Tresitope, 3,5,3'-Triiodo-L-thyronine
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
Chemical data
- Formula
- C15H12I3NO4
- Molecular weight
- 650.97 g/mol
- IUPAC name
- (2S)-2-azaniumyl-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoate
- SMILES
- C1=CC(=C(C=C1OC2=C(C=C(C=C2I)C[C@@H](C(=O)[O-])[NH3+])I)I)O
- InChIKey
- AUYYCJSJGJYCDS-LBPRGKRZSA-N
- XLogP
- 2.4
- Polar surface area
- 97.2 Ų
- H-bond donors
- 2
- H-bond acceptors
- 4
- Formal charge
- 0
via PubChem
Research
36,157 papersvia
~14 min read
Article
22 sectionsContents
- Production
- Synthesis from T<sub>4</sub>
- Direct synthesis
- Mechanism of action
- Transportation
- Effects
- Skeletal growth
- Protein
- Lipids
- Heart
- Development
- Neurotransmitters
- Physiological function
- Measurement
- Medical uses
- Treatment of depressive disorders
- Use as a fat loss supplement
- Alternative medicine
- History
- See also
- References
- External links
Triiodothyronine, also known as T3, is a thyroid hormone. It affects almost every physiological process in the body, including growth and development, metabolism, body temperature, and heart rate.
Production of T3 and its prohormone thyroxine (T4) is activated by thyroid-stimulating hormone (TSH), which is released from the anterior pituitary gland. This pathway is part of a closed-loop feedback process: Elevated concentrations of T3, and T4 in the blood plasma inhibit the production of TSH in the anterior pituitary gland. As concentrations of these hormones decrease, the anterior pituitary gland increases production of TSH, and by these processes, a feedback control system stabilizes the level of thyroid hormones in the bloodstream.