English

English Deutsch Español Français Italiano Nederlands Português Svenska

GeneQ7523191· pop 6· linked from 443 articles

TYMP

Sign in to save

Also known as thymidine phosphorylase, ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP

protein-coding gene in the species Homo sapiens

Gene data

TYMP

Name: thymidine phosphorylase
Type: protein-coding
Position: 50,525,752–50,530,326 (−)
Aliases: ECGF, ECGF1, MEDPS1, MNGIE, MTDPS1, PDECGF, TP, hPD-ECGF
Ensembl: ENSG00000025708
RefSeq RNA: NM_001113755.3, NM_001113756.3, NM_001257988.1, NM_001257989.1, NM_001953.5
RefSeq protein: NP_001107227.1, NP_001107228.1, NP_001244917.1, NP_001244918.1, NP_001944.1

This gene encodes an angiogenic factor which promotes angiogenesis in vivo and stimulates the in vitro growth of a variety of endothelial cells. It has a highly restricted target cell specificity acting only on endothelial cells. Mutations in this gene have been associated with mitochondrial neurogastrointestinal encephalomyopathy. Multiple alternatively spliced transcript variants have been identified. [provided by RefSeq, Apr 2012].

Gene Ontology

Biological process

pyrimidine nucleobase metabolic process pyrimidine nucleoside metabolic process pyrimidine nucleoside metabolic process pyrimidine nucleoside metabolic process dTMP catabolic process nucleobase-containing small molecule metabolic process pyrimidine-containing compound metabolic process carbohydrate derivative metabolic process

Molecular function

1,4-alpha-oligoglucan phosphorylase activity protein binding thymidine phosphorylase activity thymidine phosphorylase activity thymidine phosphorylase activity thymidine phosphorylase activity pyrimidine-nucleoside phosphorylase activity glycosyltransferase activity

Cellular component

cytosol cytosol

Pathways

Pyrimidine metabolism - Homo sapiens (human)Drug metabolism - other enzymes - Homo sapiens (human)Bladder cancer - Homo sapiens (human)Metabolism Metabolism of nucleotides Pyrimidine salvage Pyrimidine catabolism Nucleotide catabolism Nucleotide salvage Fluoropyrimidine Activity

via MyGene.info

Gene · Ensembl

thymidine phosphorylase

Symbol: TYMP
Biotype: Protein coding
Organism: Homo sapiens
Location: 22:50,525,752-50,530,326
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein ECGF1 PDB 1uou.png

Show 6 more facts

HomoloGene ID: 1474
exact match: identifiers.org/ncbigene/1890
genomic end: 50530032
genomic start: 50964181
Commons category: Thymidine phosphorylase
cytogenetic location: 22q13.33

Sources (5)

via Wikidata · CC0

Available in 6 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 22