WFDC2
Sign in to saveAlso known as EDDM4, HE4, WAP5, dJ461P17.6, WAP four-disulfide core domain 2
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
Gene data
WFDC2- Name
- WAP four-disulfide core domain 2
- Type
- protein-coding
- Position
- 45,469,386–45,481,533 (+)
- Aliases
- BENP, EDDM4, HE4, WAP5, dJ461P17.6
- Ensembl
- ENSG00000101443
- RefSeq RNA
- NM_006103.4, NM_080733.1, NM_080734.1, NM_080735.1, NM_080736.1
- RefSeq protein
- NP_006094.3
This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
WAP four-disulfide core domain 2
- Symbol
- WFDC2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:45,469,166-45,481,533
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
Show 5 more facts
- HomoloGene ID
- 4450
- exact match
- identifiers.org/ncbigene/10406
- genomic start
- 45469753
- cytogenetic location
- 20q13.12
- genomic end
- 44110172
Sources (4)
via Wikidata · CC0
~1 min read
Article
3 sectionsContents
- Function
- References
- Further reading
WAP four-disulfide core domain protein 2 - also known as Human Epididymis Protein 4 (HE4) - is a protein that in humans is encoded by the WFDC2 gene.
HE4 is a tumor marker of ovarian cancer, with 80% sensitivity and 99% specificity at a cut-off of 150 pmol/L.