WIF1

Also known as WIF-1, WNT inhibitory factor 1

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.

In the Vinony graph

Vinony's link graph records 7 inbound references to WIF1, and connects out to PubMed, human chromosome 12 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 12.

Vinony links it to 6 Wikipedia language editions.

Gene data

WIF1

Name: Wnt inhibitory factor 1
Type: protein-coding
Position: 65,050,565–65,121,582 (−)
Aliases: WIF-1
Ensembl: ENSG00000156076
RefSeq RNA: NM_007191.5
RefSeq protein: NP_009122.2

The protein encoded by this gene functions to inhibit WNT proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a WNT inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010].

Gene Ontology

Biological process

signal transduction negative regulation of Wnt signaling pathway

Molecular function

signaling receptor binding protein binding Wnt-protein binding

Cellular component

extracellular region extracellular region cell surface

Pathways

Wnt signaling pathway - Homo sapiens (human)Signal Transduction Signaling by WNT TCF dependent signaling in response to WNT Negative regulation of TCF-dependent signaling by WNT ligand antagonists Wnt-beta-catenin signaling pathway in leukemia LncRNA involvement in canonical Wnt signaling and colorectal cancer Wnt signaling ncRNAs involved in Wnt signaling in hepatocellular carcinoma

via MyGene.info

Gene · Ensembl

Wnt inhibitory factor 1

Symbol: WIF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 12:65,050,565-65,121,582
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein WIF1 PDB 2d3j.png

Show 8 more facts

HomoloGene ID: 31430
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/11197
genomic end: 65121305
genomic start: 65444406
chromosome: human chromosome 12
cytogenetic location: 12q14.3
expressed in: trabecular bone

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

Function
References
Further reading

Wnt inhibitory factor 1 is a protein that in humans is encoded by the WIF1 gene. WIF1 is a lipid-binding protein that binds to Wnt proteins and prevents them from triggering signalling.

== Function ==

Excerpted from Wikipedia’s “WIF1” article, available under the CC BY-SA 4.0 licence.