xipamide

Also known as BE-1293, Diurexan®, MJF-10938

Xipamide () is a sulfonamide diuretic drug marketed by Eli Lilly under the trade names Aquaphor (in Germany) and Aquaphoril (in Austria). It is used for the treatment of oedema and hypertension.

Wikidata facts

Mass: 354.044106

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chemical formula: C₁₅H₁₅ClN₂O₄S
canonical SMILES: CC1=C(C(=CC=C1)C)NC(=O)C2=CC(=C(C=C2O)Cl)S(=O)(=O)N
defined daily dose: 20
Commons category: Xipamide

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Article

12 sections

Contents

Mechanism of action
Uses
Pharmacokinetics
Dosage
Adverse effects
Contraindications
Interactions
Not recommended combinations
Combinations requiring special precautions
Interactions not included in the product information
Banned use in sport
References

Xipamide () is a sulfonamide diuretic drug marketed by Eli Lilly under the trade names Aquaphor (in Germany) and Aquaphoril (in Austria). It is used for the treatment of oedema and hypertension.

== Mechanism of action == Like the structurally related thiazide diuretics, xipamide acts on the kidneys to reduce sodium reabsorption in the distal convoluted tubule. This increases the osmolarity in the lumen, causing less water to be reabsorbed by the collecting ducts. This leads to increased urinary output. Unlike the thiazides, xipamide reaches its target from the peritubular side (blood side).