Also known as XP1, XPAC, xeroderma pigmentosum, complementation group A, XPA, DNA damage recognition and repair factor
DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. ==Function==
Gene data
XPA- Name
- XPA, DNA damage recognition and repair factor
- Type
- protein-coding
- Position
- 97,653,139–97,697,408 (−)
- Aliases
- XP1, XPAC
- Ensembl
- ENSG00000136936
- RefSeq RNA
- NM_000380.4, NM_001354975.2, NM_001446083.1, NR_027302.2, NR_149091.2
- RefSeq protein
- NP_000371.1, NP_001341904.1, NP_001433012.1, XP_006717341.1, XP_054219731.1
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
XPA, DNA damage recognition and repair factor
- Symbol
- XPA
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 9:97,653,139-97,697,408
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein XPA PDB 1d4u.png
Show 2 more facts
- exact match
- identifiers.org/ncbigene/7507
- HomoloGene ID
- 37298
Sources (7)
via Wikidata · CC0
~1 min read
Article
5 sectionsContents
- Function
- Interactions
- References
- Further reading
- External links
DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. ==Function==
Nucleotide excision repair (NER) is a major pathway for repairing a variety of bulky DNA damages including those introduced by UV irradiation. The XPA protein appears to play a key role in NER at sites of damage as a scaffold for other repair proteins in order to ensure that the damages are appropriately excised.