XPA

Also known as XP1, XPAC, xeroderma pigmentosum, complementation group A, XPA, DNA damage recognition and repair factor

DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. ==Function==

Gene data

XPA

Name: XPA, DNA damage recognition and repair factor
Type: protein-coding
Aliases: XP1, XPAC

This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017].

via MyGene.info

Wikidata facts

Image: Protein XPA PDB 1d4u.png

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Function
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DNA repair protein complementing XP-A cells (or XPA) is a protein that in humans is encoded by the XPA gene. ==Function==

Nucleotide excision repair (NER) is a major pathway for repairing a variety of bulky DNA damages including those introduced by UV irradiation. The XPA protein appears to play a key role in NER at sites of damage as a scaffold for other repair proteins in order to ensure that the damages are appropriately excised.