Structure via PubChem · Public domain (PubChem)
ziprasidone
Sign in to saveAlso known as CP-88059, CP-88059-27, CP-880591, CP-8805927, Geodon®, Ziprasidone hydrochloride, Geodon
Ziprasidone, sold under the brand name Geodon among others, is an atypical antipsychotic used to treat schizophrenia and bipolar disorder. It may be used by mouth and by injection into a muscle (IM). The intramuscular form may be used for acute agitation in people with schizophrenia.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 470637441
- Drug.image
- Ziprasidone.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.image2
- Ziprasodone-3D-Ball-And-Stick-Model.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.tradename
- Geodon, others
- Drug.MedlinePlus
- a699062
- Drug.DailyMedID
- Ziprasidone
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth, intramuscular injection (IM)
- Drug.class
- Atypical antipsychotic
- Drug.ATC_prefix
- N05
- Drug.ATC_suffix
- AE04
- Drug.legal_AU
- S4
- Drug.legal_BR
- C1
via Wikipedia infobox
Chemical data
- Formula
- C21H21ClN4OS
- Molecular weight
- 412.9 g/mol
- IUPAC name
- 5-[2-[4-(1,2-benzothiazol-3-yl)piperazin-1-yl]ethyl]-6-chloro-1,3-dihydroindol-2-one
- SMILES
- C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54
- InChIKey
- MVWVFYHBGMAFLY-UHFFFAOYSA-N
- XLogP
- 4
- Polar surface area
- 76.7 Ų
- H-bond donors
- 1
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,291 papers- Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department.Annals of emergency medicine · 2018
- Ziprasidone: a new atypical antipsychotic.Expert opinion on pharmacotherapy · 2001
- Ziprasidone: a review of its use in schizophrenia and schizoaffective disorder.Drugs · 2002
- Ziprasidone in the treatment of affective disorders: a review.CNS neuroscience & therapeutics · 2008
- Ziprasidone, a new atypical antipsychotic drug.Pharmacotherapy · 2001
via PubMed
Wikidata facts
- Mass
- 412.11246
Show 5 more facts
- chemical formula
- C₂₁H₂₁ClN₄OS
- canonical SMILES
- C1CN(CCN1CCC2=C(C=C3C(=C2)CC(=O)N3)Cl)C4=NSC5=CC=CC=C54
- World Health Organisation international non-proprietary name
- ziprasidone
- Commons category
- Ziprasidone
- defined daily dose
- 40
Sources (8)
via Wikidata · CC0
~13 min read
Article
15 sectionsContents
- Medical uses
- Adverse effects
- Discontinuation
- Pharmacology
- Pharmacodynamics
- Correspondence to clinical effects
- Pharmacokinetics
- History
- Society and culture
- Lawsuit
- Brand names
- Research
- See also
- References
- Further reading
{{Infobox drug | Watchedfields = changed | verifiedrevid = 470637441 | image = Ziprasidone.svg | image_class = skin-invert-image | width = 250px | alt = | image2 = Ziprasodone-3D-Ball-And-Stick-Model.png | image_class2 = bg-transparent | width2 = 250px | alt2 = | pronounce = | tradename = Geodon, others | Drugs.com = | MedlinePlus = a699062 | DailyMedID = Ziprasidone | pregnancy_AU = C | pregnancy_AU_comment = | pregnancy_category = | routes_of_administration = By mouth, intramuscular injection (IM) | class = Atypical antipsychotic | ATC_prefix = N05 | ATC_suffix = AE04 | ATC_supplemental = | legal_AU = S4 | legal_AU_comment = | legal_BR = C1 | legal_BR_comment = | legal_CA = | legal_CA_comment = | legal_DE = | legal_DE_comment = | legal_NZ = | legal_NZ_comment = | legal_UK = | legal_UK_comment = | legal_US = Rx-only | legal_US_comment = | legal_EU = | legal_EU_comment = | legal_UN = | legal_UN_comment = | legal_status =
| bioavailability = 60% (oral) 100% (IM) | protein_bound = | metabolism = Liver (aldehyde reductase) | metabolites = | onset = | elimination_half-life = 7 to 10 hours | duration_of_action = | excretion = Urine and feces