ACOT13

Also known as PNAS-27, THEM2, HT012, acyl-CoA thioesterase 13

Acyl-CoA thioesterase 13 is a protein that in humans is encoded by the ACOT13 gene. This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation.

In the Vinony graph

Within Vinony's link graph, ACOT13 is referenced by 20 other articles, and connects out to PubMed, human chromosome 6 and Ensembl genome database project.

It is catalogued under topics including Genes on human chromosome 6 and Proteins.

Its subject is documented across 5 Wikipedia language editions.

Gene data

ACOT13

Name: acyl-CoA thioesterase 13
Type: protein-coding
Position: 24,666,901–24,714,084 (+)
Aliases: HT012, PNAS-27, THEM2
Ensembl: ENSG00000112304
RefSeq RNA: NM_001160094.2, NM_018473.4
RefSeq protein: NP_001153566.1, NP_060943.1

This gene encodes a member of the thioesterase superfamily. In humans, the protein co-localizes with microtubules and is essential for sustained cell proliferation. The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009].

Gene Ontology

Biological process

protein homotetramerization negative regulation of cold-induced thermogenesis negative regulation of cold-induced thermogenesis

Molecular function

protein binding fatty acyl-CoA hydrolase activity fatty acyl-CoA hydrolase activity fatty acyl-CoA hydrolase activity medium-chain fatty acyl-CoA hydrolase activity long-chain fatty acyl-CoA hydrolase activity short-chain fatty acyl-CoA hydrolase activity

Cellular component

nucleus nucleus nucleus cytoplasm mitochondrion mitochondrion mitochondrion mitochondrial matrix

Pathways

Metabolism Metabolism of lipids Mitochondrial Fatty Acid Beta-Oxidation Fatty acid metabolism

via MyGene.info

Gene · Ensembl

acyl-CoA thioesterase 13

Symbol: ACOT13
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:24,666,901-24,714,084
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 41273
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/55856
genomic end: 24705293
genomic start: 24667263
chromosome: human chromosome 6
cytogenetic location: 6p22.3

Sources (4)

via Wikidata · CC0

~3 min read

Encyclopedic overview

5 sections

Contents

Structure
Function
References
External links
Further reading

== Structure == The orthologous mouse protein forms a homotetramer and is associated with mitochondria. The mouse protein functions as a medium- and long-chain acyl-CoA thioesterase. Multiple transcript variants encoding different isoforms have been found for this gene.

Excerpted from Wikipedia’s “ACOT13” article, available under the CC BY-SA 4.0 licence.