Structure via PubChem · Public domain (PubChem)
acotiamide
Sign in to saveAlso known as MZ-338
Acotiamide, sold under the brand names Acofide, and Dyspevict is a medication manufactured and approved in Japan and Russia for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia. It acts as an acetylcholinesterase inhibitor.
In the Vinony graph
Vinony's link graph records 344 inbound references to acotiamide, and connects out to botulinum toxin group, medication and chlorpyrifos.
It sits within the topics Acetylcholinesterase inhibitors, Carboxamides and Catechol ethers.
Vinony links it to 6 Wikipedia language editions.
Chemical data
- Formula
- C21H30N4O5S
- Molecular weight
- 450.6 g/mol
- IUPAC name
- N-[2-[di(propan-2-yl)amino]ethyl]-2-[(2-hydroxy-4,5-dimethoxybenzoyl)amino]-1,3-thiazole-4-carboxamide
- SMILES
- CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
- InChIKey
- TWHZNAUBXFZMCA-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 141 Ų
- H-bond donors
- 3
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- gastrointestinal disease
via ChEMBL · EBI
Research
170 papers- Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis.Cureus · 2021
- Acotiamide (Z-338, YM443), a new drug for the treatment of functional dyspepsia.Expert opinion on investigational drugs · 2011
- Profile of acotiamide in the treatment of functional dyspepsia.Clinical and experimental gastroenterology · 2016
- Acotiamide (Z-338) as a possible candidate for the treatment of functional dyspepsia.Neurogastroenterology and motility · 2010
- Acotiamide improves stress-induced impaired gastric accommodation.Neurogastroenterology and motility · 2017
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 450.193691
Show 3 more facts
- chemical formula
- C₂₁H₃₀N₄O₅S
- canonical SMILES
- CC(C)N(CCNC(=O)C1=CSC(=N1)NC(=O)C2=CC(=C(C=C2O)OC)OC)C(C)C
- Commons category
- Acotiamide
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
1 sectionsContents
- References
{{Drugbox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477240986 | image = Acotiamide.svg | image_class = skin-invert-image | width = 275
| tradename = Acofide, others | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = A03 | ATC_suffix = FA10 | ATC_supplemental =
Excerpted from Wikipedia’s “acotiamide” article, available under the CC BY-SA 4.0 licence.