ACTB
Sign in to saveAlso known as BRWS1, PS1TP5BP1, Beta-actin, actin, beta, actin beta
Beta-actin, or Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.
Gene data
ACTB- Name
- actin beta
- Type
- protein-coding
- Position
- 5,526,409–5,563,902 (−)
- Aliases
- BKRNS, BNS, BRWS1, CSMH, DDS1, PS1TP5BP1, THC8
- Ensembl
- ENSG00000075624
- RefSeq RNA
- NM_001101.5
- RefSeq protein
- NP_001092.1
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
actin beta
- Symbol
- ACTB
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 7:5,526,409-5,563,902
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein ACTB PDB 1atn.png
Show 5 more facts
- HomoloGene ID
- 110648
- exact match
- identifiers.org/ncbigene/60
- genomic start
- 5526409
- genomic end
- 5563902
- cytogenetic location
- 7p22.1
via Wikidata · CC0
~1 min read
Article
7 sectionsContents
- Interactions
- Clinical relevance
- Applications
- References
- External links
- Further reading
- See also
Beta-actin, or Actin beta (HUGO Gene Nomenclature Committee abbreviation ACTB/ACTB) is one of six different actin isoforms which have been identified in humans. This is one of the two nonmuscle cytoskeletal actins. Actins are highly conserved proteins that are involved in cell motility, structure and integrity. Alpha actins are a major constituent of the contractile apparatus.
== Interactions ==