ADGRG4

Also known as PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRG4

Name: adhesion G protein-coupled receptor G4
Type: protein-coding
Chromosome: X
Aliases: GPR112, PGR17, RP1-299I16

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].

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Gene · Ensembl

adhesion G protein-coupled receptor G4

Symbol: ADGRG4
Biotype: Protein coding
Organism: Homo sapiens
Location: Chr X:136,300,963-136,416,890
Strand: Forward (+)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 72131
exact match: identifiers.org/ncbigene/139378
genomic start: 135383122
genomic end: 136416890
cytogenetic location: Xq26.3

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GPR112 is expressed in human enterochromaffin cells and in the mouse intestine. The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules. GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.