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GeneQ18050770· pop 5· linked from 484 articles

ADGRG4

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Also known as PGR17, RP1-299I16, GPR112, adhesion G protein-coupled receptor G4

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

Gene data

ADGRG4
Name
adhesion G protein-coupled receptor G4
Type
protein-coding
Chromosome
X
Position
136,300,963–136,416,890 (+)
Aliases
GPR112, PGR17, RP1-299I16
Ensembl
ENSG00000156920
RefSeq RNA
NM_153834.4, XM_011531269.3, XM_011531271.3, XM_047441830.1, XM_047441831.1
RefSeq protein
NP_722576.3, XP_011529571.1, XP_011529573.1, XP_047297786.1, XP_047297787.1

This gene encodes a G-protein coupled receptor belonging to a large family of diverse integral membrane proteins that participate in various physiological functions. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The ligand for this family member is unknown, and it is therefore an orphan receptor. This receptor is known to be expressed in normal enterochromaffin cells and in gastrointestinal neuroendocrine carcinoma cells, and it is therefore considered to be a novel biomarker or target for immunotherapy. [provided by RefSeq, May 2010].

Gene Ontology

via MyGene.info

Gene · Ensembl

adhesion G protein-coupled receptor G4

Symbol
ADGRG4
Biotype
Protein coding
Organism
Homo sapiens
Location
Chr X:136,300,963-136,416,890
Strand
Forward (+)
Assembly
GRCh38
View on Ensembl →

via Ensembl · EMBL-EBI

~1 min read

Encyclopedic overview

2 sections
Contents
  • References
  • External links

G protein-coupled receptor 112 is a protein encoded by the ADGRG4 gene. GPR112 is a member of the adhesion GPCR family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain.

GPR112 is expressed in human enterochromaffin cells and in the mouse intestine. The N-terminal fragment (NTF) of GPR112 contains pentraxin (PTX)-like modules. GPR112 gene expression has been identified as a marker for neuroendocrine carcinoma cells.

Excerpted from Wikipedia’s “ADGRG4” article, available under the CC BY-SA 4.0 licence.

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