Structure via PubChem · Public domain (PubChem)
آیلدنافیل
Sign in to saveAildenafil (methisosildenafil) is a synthetic drug that is a structural analog of sildenafil (Viagra). It was first reported in 2003. Like sildenafil, aildenafil is a phosphodiesterase type 5 inhibitor.
Chemical data
- Formula
- C23H32N6O4S
- Molecular weight
- 488.6 g/mol
- IUPAC name
- 5-[5-[(3S,5R)-3,5-dimethylpiperazin-1-yl]sulfonyl-2-ethoxyphenyl]-1-methyl-3-propyl-4H-pyrazolo[4,5-d]pyrimidin-7-one
- SMILES
- CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4C[C@H](N[C@H](C4)C)C)OCC)C
- InChIKey
- NFSWSZIPXJAYLR-GASCZTMLSA-N
- XLogP
- 1.9
- Polar surface area
- 126 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Research
15 papers- Safety, tolerability, and pharmacokinetics of aildenafil citrate tablets, a novel oral PDE5 inhibitor, in healthy Chinese volunteers after multiple-dose administration.Sexual medicine · 2024
- Efficacy and safety of aildenafil citrate in Chinese men with erectile dysfunction: a multicenter, randomized, double-blind, placebo-controlled crossover trial.Translational andrology and urology · 2021
- [Aildenafil citrate: a new potent and highly selective phosphodiesterase type 5 inhibitor for the treatment of erectile dysfunction].Zhonghua nan ke xue = National journal of andrology · 2006
- Metabolism of aildenafil in vivo in rats and in vitro in mouse, rat, dog, and human liver microsomes.Drug testing and analysis · 2014
- Structural elucidation of propoxyphenyl isobutyl aildenafil, adulterant in a health supplement using high-resolution Orbitrap mass spectrometry.Journal of pharmaceutical and biomedical analysis · 2014
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 488.22057450399996
Show 3 more facts
- canonical SMILES
- CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4CC(NC(C4)C)C)OCC)C
- chemical formula
- C₂₃H₃₂N₆O₄S
- isomeric SMILES
- CCCC1=NN(C2=C1NC(=NC2=O)C3=C(C=CC(=C3)S(=O)(=O)N4C[C@H](N[C@H](C4)C)C)OCC)C
Sources (2)
via Wikidata · CC0