ATOX1
Sign in to saveAlso known as ATX1, HAH1, antioxidant 1 copper chaperone
ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B. Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae as ATX1, and all contain a conserved metal binding domain.
Gene data
ATOX1- Name
- antioxidant 1 copper chaperone
- Type
- protein-coding
- Aliases
- ATX1, HAH1
This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008].
via MyGene.info
Gene · Ensembl
antioxidant 1 copper chaperone
- Symbol
- ATOX1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 5:151,728,919-151,772,532
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein ATOX1 PDB 1fe0.png
Show 5 more facts
- exact match
- identifiers.org/ncbigene/475
- HomoloGene ID
- 2984
- genomic end
- 151152093
- genomic start
- 151121877
- cytogenetic location
- 5q33.1
Sources (4)
via Wikidata · CC0
~4 min read
Article
7 sectionsContents
- Function
- Structure & metal coordination
- Metal transfer
- Clinical significance
- References
- External links
- Further reading
ATOX1 is a copper metallochaperone protein that is encoded by the ATOX1 gene in humans. In mammals, ATOX1 plays a key role in copper homeostasis as it delivers copper from the cytosol to transporters ATP7A and ATP7B. Homologous proteins are found in a wide variety of eukaryotes, including Saccharomyces cerevisiae as ATX1, and all contain a conserved metal binding domain.
== Function ==