TMC8

Also known as EV2, EVER2, EVIN2, transmembrane channel like 8

Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene.

Gene data

TMC8

Name: transmembrane channel like 8
Type: protein-coding
Position: 78,130,770–78,142,968 (+)
Aliases: EV2, EVER2, EVIN2
Ensembl: ENSG00000167895
RefSeq RNA: NM_152468.5
RefSeq protein: NP_689681.2

Epidermodysplasia verruciformis (EV) is an autosomal recessive dermatosis characterized by abnormal susceptibility to human papillomaviruses (HPVs) and a high rate of progression to squamous cell carcinoma on sun-exposed skin. EV is caused by mutations in either of two adjacent genes located on chromosome 17q25.3. Both of these genes encode integral membrane proteins that localize to the endoplasmic reticulum and are predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

intracellular zinc ion homeostasis

Article

4 sections

Contents

Function
Clinical significance
References
Further reading

Transmembrane channel-like protein 8 is a protein which in humans is encoded by the TMC8 gene.

==Function== The protein encoded by this gene is an integral membrane protein that localize to the endoplasmic reticulum and is predicted to form transmembrane channels. This gene encodes a transmembrane channel-like protein with 8 predicted transmembrane domains and 3 leucine zipper motifs.