ATPase copper transporting beta
Sign in to saveAlso known as copper-transporting ATPase 2, ATPase, Cu(2+)- transporting, beta polypeptide, copper pump 2, ATP7B, Wilson disease-associated protein, copper-transporting protein ATP7B, ATPase, Cu++ transporting, beta polypeptide, ATP7B protein, human
mammalian protein found in Homo sapiens
Protein · UniProt
Copper-transporting ATPase 2
- Gene
- ATP7B
- Organism
- Homo sapiens (Human)
- Length
- 1,465 aa
- Molecular mass
- 157,263 Da
- Evidence
- 1: Evidence at protein level
Copper ion transmembrane transporter involved in the export of copper out of the cells. It is involved in copper homeostasis in the liver, where it ensures the efflux of copper from hepatocytes into the bile in response to copper overload
3D-structureAlternative splicingATP-bindingCopperCopper transportCytoplasmDisease variantEndosome
View on UniProt →
Swiss-Prot (reviewed) · via UniProt
Research
781 papersvia PubMed
Clinical Trials
51 registered- COMPLETEDEstablishment of Human Cellular Disease Models for Wilson DiseaseCENTOGENE GmbH Rostock · NCT03867526
- PHASE3COMPLETEDStudy of Tetrathiomolybdate in Patients With Wilson DiseaseNational Center for Research Resources (NCRR) · NCT00004339
- UNKNOWNEvaluation of Cognitive Dysfunction and Psychiatric ComorbiditiesAssiut University · NCT06179394
- PHASE4UNKNOWNStudy to Assess Long-Term Outcomes of Trientine in Wilson Disease Patients Withdrawn From Therapy With d-PenicillamineUnivar BV · NCT02426905
- PHASE3TERMINATEDStudy of ALXN1840 Versus Standard of Care in Pediatric Participants With Wilson DiseaseAlexion Pharmaceuticals, Inc. · NCT05047523
- EARLY_PHASE1RECRUITINGA Clinical Study on the Treatment of Wilson Disease With ATP7B mRNA/LNP (DSL101)DSciLab Co., Ltd. · NCT07240896