Hephaestin
Sign in to saveAlso known as HEPH
Hephaestin, also known as HEPH, is a protein which in humans is encoded by the HEPH gene.
Protein · UniProt
Hephaestin
- Gene
- HEPH
- Organism
- Homo sapiens (Human)
- Length
- 1,158 aa
- Molecular mass
- 130,449 Da
- Evidence
- 1: Evidence at protein level
Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body (PubMed:22961397, PubMed:37277838). By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity)
Swiss-Prot (reviewed) · via UniProt
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- Commons category
- Hephaestin
Sources (3)
via Wikidata · CC0
~7 min read
Article
7 sectionsContents
- Function
- Discovery
- Structure
- Regulation
- Relevance in biology and disease
- See also
- References
Hephaestin, also known as HEPH, is a protein which in humans is encoded by the HEPH gene.
==Function==