azilsartan

Also known as TAK 536, TAK-536, TAK536

Azilsartan, sold under the brand name Edarbi among others, is used for the treatment of hypertension. It is used as the prodrug azilsartan medoxomil, is an angiotensin II receptor antagonist, and was developed by Takeda.

Key facts

Drug.legal_status: Rx-only
Drug.bioavailability: 60%
Drug.Verifiedfields: changed
Drug.Watchedfields: changed
Drug.verifiedrevid: 456077928
Drug.image: Azilsartan.svg
Drug.image_class: skin-invert-image
Drug.tradename: Edarbi, Azilva
Drug.MedlinePlus: a611028
Drug.DailyMedID: Azilsartan
Drug.routes_of_administration: By mouth
Drug.ATC_prefix: C09
Drug.ATC_suffix: CA09
Drug.legal_CA: Rx-only
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.legal_EU: Rx-only
Drug.metabolism: CYP2C9

via Wikipedia infobox

Chemical data

Formula: C25H20N4O5
Molecular weight: 456.4 g/mol
IUPAC name: 2-ethoxy-3-[[4-[2-(5-oxo-4H-1,2,4-oxadiazol-3-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylic acid
SMILES: CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O
InChIKey: KGSXMPPBFPAXLY-UHFFFAOYSA-N
XLogP: 4.4
Polar surface area: 115 Å²
H-bond donors: 2
H-bond acceptors: 7
Formal charge: 0

via PubChem

~6 min read

Encyclopedic overview

9 sections

Contents

Medical uses
Contraindications
Interactions
Pharmacology
Mechanism of action
Pharmacokinetics
Chemistry
History
References

{{Infobox drug | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 456077928 | image = Azilsartan.svg | image_class = skin-invert-image | width = | alt = | caption = | USAN =

Excerpted from Wikipedia’s “azilsartan” article, available under the CC BY-SA 4.0 licence.