BACE2
Sign in to saveAlso known as AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
protein-coding gene in the species Homo sapiens
Gene data
BACE2- Name
- beta-secretase 2
- Type
- protein-coding
- Aliases
- AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
via MyGene.info
Gene · Ensembl
beta-secretase 2
- Symbol
- BACE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:41,167,775-41,282,530
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein BACE2 PDB 2ewy.png
Show 5 more facts
- HomoloGene ID
- 22696
- exact match
- identifiers.org/ncbigene/25825
- genomic end
- 41282530
- genomic start
- 42539728
- cytogenetic location
- 21q22.2-q22.3
Sources (4)
via Wikidata · CC0
Connections
aspartate protease
Entity
Q180686
Entity
Online Mendelian Inheritance in Man
Entity
human chromosome 21
Entity
Ensembl genome database project
Entity
enzyme
Entity
Giant panda
Entity
Wikidata
Entity
Alzheimer's disease
Entity
chromosome
Entity
digital object identifier
Entity
International Standard Serial Number
Entity
Down syndrome
Entity
L-alanine
Entity
DL-glutamic acid
Entity
L-aspartic acid
Entity
L-valine
Entity
L-leucine
Entity
bibcode
Entity
phenylalanine
Entity