BACE2
Sign in to saveAlso known as AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
gène de l'espèce Homo sapiens
In the Vinony graph
Vinony's link graph records 206 inbound references to BACE2, and connects out to aspartate protease, PubMed and Online Mendelian Inheritance in Man.
Vinony files it under EC 3.4.23 and Genes on human chromosome 21.
Vinony links it to 4 Wikipedia language editions.
Gene data
BACE2- Name
- beta-secretase 2
- Type
- protein-coding
- Position
- 41,167,775–41,282,530 (+)
- Aliases
- AEPLC, ALP56, ASP1, ASP21, BAE2, CDA13, CEAP1, DRAP
- Ensembl
- ENSG00000182240
- RefSeq RNA
- NM_012105.5, NM_138991.3, NM_138992.3, XM_017028314.2, XM_054324423.1
- RefSeq protein
- NP_036237.2, NP_620476.1, NP_620477.1, XP_016883803.1, XP_054180398.1
This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].
Gene Ontology
Biological process
Molecular function
via MyGene.info
Gene · Ensembl
beta-secretase 2
- Symbol
- BACE2
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 21:41,167,775-41,282,530
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein BACE2 PDB 2ewy.png
Show 7 more facts
- HomoloGene ID
- 22696
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/25825
- genomic end
- 41282530
- genomic start
- 42539728
- chromosome
- human chromosome 21
- cytogenetic location
- 21q22.2-q22.3
Sources (4)
via Wikidata · CC0