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bile acids
Sign in to saveAlso known as Bile Acids and Salts, biliary acid
steroid acids and salts, derived from cholesterol in the liver and usually conjugated with glycine or taurine, and sometimes further modified by bacteria in the intestine
Research
57,077 papers- Planar bile acids in health and disease.Biochimica et biophysica acta. Biomembranes · 2017
- [BILE ACIDS].Recenti progressi in medicina · 1964
- [Physiopathology of bile acids].Medicina · 1971
- The enterohepatic circulation of bile acids in man.Clinics in gastroenterology · 1977
- The significance of bile acids in gastrointestinal and hepatic disease.Disease-a-month : DM · 1971
via PubMed
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- Bile acids
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Article
Bile acids are steroid acids found predominantly in the bile of mammals and other vertebrates. Diverse bile acids are synthesized in the liver in peroxisomes. Bile acids are conjugated with taurine or glycine residues to give anions called bile salts.
Primary bile acids are those synthesized by the liver. Secondary bile acids result from bacterial actions in the colon. In humans, taurocholic acid and glycocholic acid (derivatives of cholic acid) and taurochenodeoxycholic acid and glycochenodeoxycholic acid (derivatives of chenodeoxycholic acid) are the major bile salts. The salts of their 7-alpha-dehydroxylated derivatives, deoxycholic acid and lithocholic acid, are also found, with derivatives of cholic, chenodeoxycholic and deoxycholic acids accounting for over 90% of human biliary bile acids.