bioconjugation
Sign in to savethumb|Monoclonal antibody ibritumomab conjugated with [[tiuxetan]] Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. Methods to conjugate biomolecules are applied in various fields, including medicine, diagnostics, biocatalysis and materials. Synthetically modified biomolecules can have diverse functionalities, such as tracking cellular events, revealing enzyme function, determining protein biodistribution, imaging specific biomarkers, vaccination and delivering drugs to targeted cells.
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Article
22 sectionsContents
- Common Bioconjugation Reactions
- Reaction with Natural Amino Acids
- Reactions of lysines
- Reactions of cysteines
- Reactions of tyrosines
- Reactions of N- and C- termini
- Bioorthogonal Reactions: On Unique Functional Groups
- Modification of ketones and aldehydes
- Staudinger ligation with azides
- Huisgen cyclization of azides
- Copper catalyzed Huisgen cyclization of azides
- Strain promoted Huisgen cyclization of azides
- Transition Metal-Mediated Bioconjugation Reactions
- Alkylation
- On Natural Amino Acids
- Arylation
- On Natural Amino Acids
- On Unnatural Amino Acids
- Examples of Applied Bioconjugation Techniques
- Growth Factors
- See also
- References
thumb|Monoclonal antibody ibritumomab conjugated with [[tiuxetan]] Bioconjugation is a chemical strategy to form a stable covalent link between two molecules, at least one of which is a biomolecule. Methods to conjugate biomolecules are applied in various fields, including medicine, diagnostics, biocatalysis and materials. Synthetically modified biomolecules can have diverse functionalities, such as tracking cellular events, revealing enzyme function, determining protein biodistribution, imaging specific biomarkers, vaccination and delivering drugs to targeted cells.
Bioconjugation is a crucial strategy that links these modified biomolecules with different substrates. Besides applications in biomedical research, bioconjugation has recently also gained importance in nanotechnology such as bioconjugated quantum dots.