Structure via PubChem · Public domain (PubChem)
carvedilol
Sign in to saveAlso known as (+-)-1-(carbazol-4-yloxy)-3-((2-(o-methoxyphenoxy)ethyl)amino)-2-propanol, DQ 2466, SKF 105517, (+-)-1-(carbazol-4-yloxy)-3-((2-(O-methoxyphenoxy)ethyl)amino)-2-propanol
Carvedilol, sold under the brand name Coreg among others, is a beta blocker medication, that may be prescribed for the treatment of high blood pressure (hypertension) and chronic heart failure with reduced ejection fraction (also known as HFrEF or systolic heart failure). Beta-blockers as a collective medication class are not recommended as routine first-line treatment of high blood pressure for all patients, due to evidence demonstrating less effective cardiovascular protection and a less favourable safety profile when compared to other classes of blood pressure-lowering medications.
Key facts
- Drug.verifiedrevid
- 457636154
- Drug.image
- Carvedilol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 250px
- Drug.image2
- Carvedilol-I-3D-balls.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250px
- Drug.tradename
- Coreg, others
- Drug.MedlinePlus
- a697042
- Drug.DailyMedID
- Carvedilol
- Drug.routes_of_administration
- By mouth
- Drug.class
- Non-selective beta blocker; Alpha-1 blocker
- Drug.ATC_prefix
- C07
- Drug.ATC_suffix
- AG02
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- 25–35%
- Drug.protein_bound
- 98%
- Drug.metabolism
- Liver (CYP2D6, CYP2C9)
via Wikipedia infobox
Chemical data
- Formula
- C24H26N2O4
- Molecular weight
- 406.5 g/mol
- IUPAC name
- 1-(9H-carbazol-4-yloxy)-3-[2-(2-methoxyphenoxy)ethylamino]propan-2-ol
- SMILES
- COC1=CC=CC=C1OCCNCC(COC2=CC=CC3=C2C4=CC=CC=C4N3)O
- InChIKey
- OGHNVEJMJSYVRP-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 75.7 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
4,535 papers- Carvedilol sensitizes chemotherapy by targeting STING to boost anti-tumor immunity.Cell reports · 2025
- Carvedilol.Profiles of drug substances, excipients, and related methodology · 2013
- Carvedilol and traditional nonselective beta blockers for the secondary prophylaxis of variceal hemorrhage and portal hypertension related complications among patients with decompensated cirrhosis: a systematic review and network meta-analysis.Hepatology international · 2025
- Carvedilol and bisoprolol as initial therapy for adult hypertension without compelling indications.Hypertension research : official journal of the Japanese Society of Hypertension · 2019
- Mechanistic insights into carvedilol's potential protection against doxorubicin-induced cardiotoxicity.European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences · 2024
via PubMed
~9 min read
Encyclopedic overview
17 sectionsContents
- Medical uses
- Available forms
- Contraindications
- Side effects
- Interactions
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Elimination
- Chemistry
- History
- References
- Further reading
- External links
Carvedilol, sold under the brand name Coreg among others, is a beta blocker medication, that may be prescribed for the treatment of high blood pressure (hypertension) and chronic heart failure with reduced ejection fraction (also known as HFrEF or systolic heart failure). Beta-blockers as a collective medication class are not recommended as routine first-line treatment of high blood pressure for all patients, due to evidence demonstrating less effective cardiovascular protection and a less favourable safety profile when compared to other classes of blood pressure-lowering medications.
Common side effects include dizziness, tiredness, slowed heart rate, low blood pressure, nausea, and shortness of breath. Severe side effects may include bronchospasm. Safety during pregnancy or breastfeeding is unclear. Use is not recommended in those with liver problems. Carvedilol is a nonselective beta blocker and alpha-1 blocker. How it improves outcomes is not entirely clear but may involve dilation of blood vessels.
Excerpted from Wikipedia’s “carvedilol” article, available under the CC BY-SA 4.0 licence.