File:Bisoprolol.svg · Wikimedia Commons · See Wikimedia Commons
bisoprolol
Sign in to saveAlso known as (RS)-1-(4-(2-Isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol, EMD-33512, (+-)-1-((alpha-(2-Isopropoxyethoxy)-p-tolyl)oxy)-3-(isopropylamino)-2-propanol, Congescor, (+-)-1-((alpha-(2-Isopropoxyethoxy)-P-tolyl)oxy)-3-(isopropylamino)-2-propanol, CL-297939, Zebeta®, (RS)-1-(4-(2-isopropoxyethoxymethyl)phenoxy)-3-(isopropylamino)-2-propanol
Bisoprolol, sold under the brand names Bisotab, Concor, Corbis and Zebeta among others, is a beta blocker which is selective for the beta-1 receptor and used for cardiovascular diseases, including tachyarrhythmias, high blood pressure, angina, and heart failure. It is taken by mouth.
Key facts
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 459980153
- Drug.image
- Bisoprolol.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 240
- Drug.image2
- Bisoprolol ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.chirality
- Racemic mixture
- Drug.tradename
- Zebeta, Monocor, others
- Drug.MedlinePlus
- a693024
- Drug.pregnancy_AU
- C
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- C07
- Drug.ATC_suffix
- AB07
- Drug.legal_CA
- Rx-only
- Drug.legal_US
- Rx-only
- Drug.legal_status
- Rx-only
- Drug.bioavailability
- >90%
via Wikipedia infobox
Chemical data
- Formula
- C18H31NO4
- Molecular weight
- 325.4 g/mol
- IUPAC name
- 1-(propan-2-ylamino)-3-[4-(2-propan-2-yloxyethoxymethyl)phenoxy]propan-2-ol
- SMILES
- CC(C)NCC(COC1=CC=C(C=C1)COCCOC(C)C)O
- InChIKey
- VHYCDWMUTMEGQY-UHFFFAOYSA-N
- XLogP
- 1.9
- Polar surface area
- 60 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
2,325 papers- Beta-blockers for the treatment of arrhythmias: Bisoprolol - a systematic review.Annales pharmaceutiques francaises · 2022
- Pharmacogenetic polymorphisms affecting bisoprolol response.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2021
- Bisoprolol: A comprehensive profile.Profiles of drug substances, excipients, and related methodology · 2021
- Bisoprolol: is this just another beta-blocker for hypertension or angina?The Annals of pharmacotherapy · 1995
- Bisoprolol: a review of its use in chronic heart failure.Drugs · 2002
via PubMed
~8 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Side effects
- Cautions
- Pharmacology
- Mechanism of action
- β<sub>1</sub>-selectivity
- Renin-angiotensin system
- Pharmacokinetics
- Chemistry
- References
{{Infobox drug | Watchedfields = changed | verifiedrevid = 459980153 | image = Bisoprolol.svg | image_class = skin-invert-image | width = 240 | alt = | image2 = Bisoprolol ball-and-stick.png | image_class2 = bg-transparent | alt2 = | chirality = Racemic mixture
| tradename = Zebeta, Monocor, others | Drugs.com = | MedlinePlus = a693024 | pregnancy_AU = C | pregnancy_category = | routes_of_administration = By mouth | ATC_prefix = C07 | ATC_suffix = AB07
Excerpted from Wikipedia’s “bisoprolol” article, available under the CC BY-SA 4.0 licence.