Structure via PubChem · Public domain (PubChem)
fingolimod
Sign in to saveAlso known as FTY720, FTY-720
Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, used for the treatment of multiple sclerosis. Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period.
Key facts
- Drug.Verifiedfields
- changed
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 477167308
- Drug.image
- Fingolimod structure.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 275
- Drug.image2
- Fingolimod-3D-balls-by-AHRLS-2011.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 275
- Drug.tradename
- Gilenya
- Drug.MedlinePlus
- a611006
- Drug.DailyMedID
- Fingolimod
- Drug.pregnancy_AU
- D
- Drug.routes_of_administration
- By mouth
- Drug.class
- Immunosuppressants
- Drug.ATC_prefix
- L04
- Drug.ATC_suffix
- AE01
- Drug.legal_AU
- S4
via Wikipedia infobox
Chemical data
- Formula
- C19H33NO2
- Molecular weight
- 307.5 g/mol
- IUPAC name
- 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol
- SMILES
- CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
- InChIKey
- KKGQTZUTZRNORY-UHFFFAOYSA-N
- XLogP
- 4.2
- Polar surface area
- 66.5 Ų
- H-bond donors
- 3
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
- 307.251129
Show 5 more facts
- Commons category
- Fingolimod
- chemical formula
- C₁₉H₃₃NO₂
- canonical SMILES
- CCCCCCCCC1=CC=C(C=C1)CCC(CO)(CO)N
- World Health Organisation international non-proprietary name
- fingolimod
- defined daily dose
- 0.5
Sources (9)
via Wikidata · CC0
~9 min read
Article
8 sectionsContents
- Medical uses
- Adverse effects
- Structure and mechanism
- History
- Society and culture
- Legal status
- Research
- References
Fingolimod, sold under the brand name Gilenya, is an immunomodulating medication, used for the treatment of multiple sclerosis. Fingolimod is a sphingosine-1-phosphate receptor modulator, which sequesters lymphocytes in lymph nodes, preventing them from contributing to an autoimmune reaction. It has been reported to reduce the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period.
==Medical uses== Fingolimod is used in the treatment of the relapsing form of multiple sclerosis. Its effect in those with primary progressive multiple sclerosis is not clear. It may also be used in chronic inflammatory demyelinating polyneuropathy.