Structure via PubChem · Public domain (PubChem)
brinzolamide
Sign in to saveBrinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Chemical data
- Formula
- C12H21N3O5S3
- Molecular weight
- 383.5 g/mol
- IUPAC name
- (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
- SMILES
- CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
- InChIKey
- HCRKCZRJWPKOAR-JTQLQIEISA-N
- XLogP
- -0.3
- Polar surface area
- 164 Ų
- H-bond donors
- 2
- H-bond acceptors
- 9
- Formal charge
- 0
via PubChem
Research
508 papers- Brinzolamide.2006
- Brinzolamide.Expert opinion on pharmacotherapy · 2008
- Preclinical overview of brinzolamide.Survey of ophthalmology · 2000
- Brinzolamide/brimonidine: a review of its use in patients with open-angle glaucoma or ocular hypertension.Drugs & aging · 2015
- Brinzolamide-induced Follicular Conjunctivitis.Journal of glaucoma · 2018
via PubMed
~4 min read
Encyclopedic overview
16 sectionsContents
- Chemistry
- Indications
- Pharmacodynamics
- Pharmacokinetics
- Absorption
- Distribution
- Metabolism
- Excretion
- Cautions
- Side effects
- Precautions
- Combinations
- With timolol
- With brimonidine
- References
- Further reading
Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Brinzolamide was approved as a generic medication in the United States in November 2020.
Excerpted from Wikipedia’s “brinzolamide” article, available under the CC BY-SA 4.0 licence.