Structure via PubChem · Public domain (PubChem)
dorzolamide
Sign in to saveAlso known as Trusopt®, (4S,6S)-4-ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide, (4S,trans)-4-(ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, 4S,6S-dorzolamide, (4S,trans)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide, Dorzolamidum, (4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda*6*-thieno[2,3-b]thiopyran-2-sulfonic acid amide
Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma. It is used as an eye drop. Effects begin within three hours and last for at least eight hours. It is also available as the combination dorzolamide/timolol.
Chemical data
- Formula
- C10H16N2O4S3
- Molecular weight
- 324.4 g/mol
- IUPAC name
- (4S,6S)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
- SMILES
- CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
- InChIKey
- IAVUPMFITXYVAF-XPUUQOCRSA-N
- XLogP
- 0.4
- Polar surface area
- 151 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1994
- Admin. routes
- topical
- Indications
- open-angle glaucoma, wet macular degeneration, ocular hypertension, glaucoma
via ChEMBL · EBI
Research
1,317 papers- Dorzolamide/Timolol Fixed Combination: Learning from the Past and Looking Toward the Future.Advances in therapy · 2021
- Clinical pharmacokinetics of dorzolamide.Clinical pharmacokinetics · 2002
- Topical dorzolamide 2%/timolol 0.5%: a review of its use in the treatment of open-angle glaucoma.Drugs & aging · 2000
- Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension.Drugs & aging · 1997
- Dorzolamide: development and clinical application of a topical carbonic anhydrase inhibitor.Survey of ophthalmology · 1997
via PubMed
Wikidata facts
- Mass
- 324.027
- Has use
- medication
Show 8 more facts
- chemical formula
- C₁₀H₁₆N₂O₄S₃
- Commons category
- Dorzolamide
- medical condition treated
- glaucoma
- World Health Organisation international non-proprietary name
- dorzolamide
- isomeric SMILES
- CCN[C@H]1C[C@@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
- canonical SMILES
- CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C
- defined daily dose
- 0.3
- subject has role
- antihypertensive drug
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Side effects
- Pharmacology
- Pharmacodynamics
- Pharmacokinetics
- History
- References
- Further reading
Dorzolamide, sold under the brand name Trusopt among others, is a medication used to treat high pressure inside the eye, including in cases of glaucoma. It is used as an eye drop. Effects begin within three hours and last for at least eight hours. It is also available as the combination dorzolamide/timolol.
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Serious side effects include Steven Johnson syndrome. Those allergic to sulfonamides may be allergic to dorzolamide. Use is not recommended in pregnancy or breastfeeding. It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humor.
Excerpted from Wikipedia’s “dorzolamide” article, available under the CC BY-SA 4.0 licence.