BRMS1

Also known as breast cancer metastasis suppressor 1, BRMS1, transcriptional repressor and anoikis regulator, BRMS1 transcriptional repressor and anoikis regulator

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

In the Vinony graph

Within Vinony's link graph, BRMS1 is referenced by 2 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 11.

Its subject is documented across 5 Wikipedia language editions.

Gene data

BRMS1

Name: BRMS1 transcriptional repressor and anoikis regulator
Type: protein-coding
Position: 66,337,332–66,345,136 (−)
Ensembl: ENSG00000174744
RefSeq RNA: NM_001024957.2, NM_001024958.1, NM_015399.4, XM_024448425.2, XM_024448426.2
RefSeq protein: NP_001020128.1, NP_056214.1, XP_024304193.1, XP_024304194.1, XP_054224321.1

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II negative regulation of cell migration negative regulation of transforming growth factor beta receptor signaling pathway regulation of apoptotic process negative regulation of DNA-templated transcription positive regulation of protein deacetylation negative regulation of stem cell population maintenance

Molecular function

protein binding histone deacetylase binding NF-kappaB binding

Cellular component

nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm cytoplasm Sin3-type complex

Pathways

Disease HDACs deacetylate histones Chromatin modifying enzymes Chromatin organization Infectious disease Potential therapeutics for SARS SARS-CoV Infections Viral Infection Pathways

via MyGene.info

Gene · Ensembl

BRMS1 transcriptional repressor and anoikis regulator

Symbol: BRMS1
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:66,337,332-66,345,136
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 32260
genomic end: 66345125
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/25855
genomic start: 66104804
chromosome: human chromosome 11
cytogenetic location: 11q13.2

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

3 sections

Contents

References
External links
Further reading

Breast cancer metastasis suppressor 1 is a protein that in humans is encoded by the BRMS1 gene.

This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus, and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.

Excerpted from Wikipedia’s “BRMS1” article, available under the CC BY-SA 4.0 licence.