butofilolol

Butofilolol (trade name Cafide) is a beta-blocker drug for the treatment of essential hypertension (high blood pressure). It is not known to be marketed anywhere.

Research

10 papers

[Long-term hypotensive treatment by butofilolol].Annales de cardiologie et d'angeiologie · 1983
Butofilolol pharmacokinetics in chronic renal insufficiency.International journal of clinical pharmacology research · 1984
Pharmacokinetics of butofilolol (CAFIDE) after repeated oral administration in man.International journal of clinical pharmacology research · 1984
[Changes in sweating during exertion. Effects of beta-blocker treatment].Archives des maladies du coeur et des vaisseaux · 1984
[Evaluation of the acute hemodynamic effects of butofilolol in the arterial hypertensive patient. Comparison with propranolol and atenolol].Annales de cardiologie et d'angeiologie · 1984

via PubMed

Wikidata facts

Mass: 311.19

Show 2 more facts

canonical SMILES: CCCC(=O)C1=C(C=CC(=C1)F)OCC(CNC(C)(C)C)O
chemical formula: C₁₇H₂₆FNO₃

Sources (2)

via Wikidata · CC0

~1 min read

Article

2 sections

Contents

Synthesis
References

Butofilolol (trade name Cafide) is a beta-blocker drug for the treatment of essential hypertension (high blood pressure). It is not known to be marketed anywhere.

It is an example of a butyrophenone. ==Synthesis== 500px The Fries rearrangement of the ester formed by 4-fluorophenol (1) and butryryl chloride (2) gives 5'-fluoro-2'-hydroxybutyrophenone (3). Treatment with epichlorohydrin in the presence of base leads to 1-[5-fluoro-2-(oxiranylmethoxy)phenyl]butan-1-one (4). Lastly, reaction with tert-butylamine gives butofilolol.