CALU

Also known as calumenin

Calumenin is a protein that in humans is encoded by the CALU gene.

Gene data

CALU

Name: calumenin
Type: protein-coding
Position: 128,739,292–128,773,400 (+)
Ensembl: ENSG00000128595
RefSeq RNA: NM_001130674.3, NM_001199671.2, NM_001199672.2, NM_001199673.2, NM_001199674.1
RefSeq protein: NP_001124146.1, NP_001186600.1, NP_001186601.1, NP_001186602.1, NP_001210.1

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].

Gene Ontology

Molecular function

calcium ion binding calcium ion binding calcium ion binding

Article

3 sections

Contents

References
External links
Further reading

Calumenin is a protein that in humans is encoded by the CALU gene.

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.