CALU

Also known as calumenin

Calumenin is a protein that in humans is encoded by the CALU gene.

Gene data

CALU

Name: calumenin
Type: protein-coding
Position: 128,739,292–128,773,400 (+)
Ensembl: ENSG00000128595
RefSeq RNA: NM_001130674.3, NM_001199671.2, NM_001199672.2, NM_001199673.2, NM_001199674.1
RefSeq protein: NP_001124146.1, NP_001186600.1, NP_001186601.1, NP_001186602.1, NP_001210.1

The product of this gene is a calcium-binding protein localized in the endoplasmic reticulum (ER) and it is involved in such ER functions as protein folding and sorting. This protein belongs to a family of multiple EF-hand proteins (CERC) that include reticulocalbin, ERC-55, and Cab45 and the product of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008].

Gene Ontology

Molecular function

calcium ion binding calcium ion binding calcium ion binding calcium ion binding protein binding

Cellular component

extracellular region extracellular region endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum endoplasmic reticulum lumen endoplasmic reticulum membrane

Pathways

Hemostasis Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)Metabolism of proteins Post-translational protein modification Platelet activation, signaling and aggregation Response to elevated platelet cytosolic Ca2+Post-translational protein phosphorylation NOTCH1 regulation of endothelial cell calcification VEGFA-VEGFR2 Signaling Pathway

via MyGene.info

Gene · Ensembl

calumenin

Symbol: CALU
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:128,739,292-128,773,400
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Show 5 more facts

HomoloGene ID: 936
exact match: identifiers.org/ncbigene/813
genomic end: 128773400
genomic start: 128379346
cytogenetic location: 7q32.1

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Calumenin is a protein that in humans is encoded by the CALU gene.

Calumenin (CALU) is a calcium-binding protein localized in the endoplasmic reticulum (ER) and is involved in such ER functions as protein folding and sorting. Calumenin is a member of the EF-hand superfamily in the ER and Golgi apparatus named CERC. CERC is an acronym for its family members Cab-45, reticulocalbin, Erc-55 (RCN2), and calumenin. The CALU gene encodes a deduced 315-amino acid protein containing 6 EF-hand motifs, 1 potential N-glycosylation site, and a C-terminal ER retention signal. The human and mouse CALU proteins are 98% identical. CALU mRNA is ubiquitously expressed in human tissues and maps to 7q32.