CASC3

Also known as BTZ, MLN51, cancer susceptibility candidate 3, cancer susceptibility 3, CASC3, exon junction complex subunit, CASC3 exon junction complex subunit

Protein CASC3 is a protein that in humans is encoded by the CASC3 gene.

Gene data

CASC3

Name: CASC3 exon junction complex subunit
Type: protein-coding
Position: 40,140,278–40,177,001 (+)
Aliases: BTZ, MLN51
Ensembl: ENSG00000108349
RefSeq RNA: NM_007359.5, XM_005257163.3, XM_047435623.1, XM_047435624.1, XM_054315480.1
RefSeq protein: NP_031385.2, XP_005257220.1, XP_047291579.1, XP_047291580.1, XP_054171455.1

The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles. [provided by RefSeq, Jul 2008].