CDC42EP3

Also known as BORG2, CEP3, UB1, CDC42 effector protein 3

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

In the Vinony graph

Within Vinony's link graph, CDC42EP3 is referenced by 3 other articles, and connects out to PubMed, human chromosome 2 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 2.

Its subject is documented across 5 Wikipedia language editions.

Gene data

CDC42EP3

Name: CDC42 effector protein 3
Type: protein-coding
Position: 37,641,882–37,738,468 (−)
Aliases: BORG2, CEP3, UB1
Ensembl: ENSG00000163171
RefSeq RNA: NM_001270436.2, NM_001270437.2, NM_001270438.2, NM_001371569.1, NM_001371570.1
RefSeq protein: NP_001257365.1, NP_001257366.1, NP_001257367.1, NP_001358498.1, NP_001358499.1

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

Gene Ontology

Biological process

signal transduction Rho protein signal transduction regulation of cell shape positive regulation of actin filament polymerization positive regulation of pseudopodium assembly

Molecular function

protein binding cytoskeletal regulatory protein binding small GTPase binding

Cellular component

cytoplasm cytoplasm cytosol cytoskeleton cytoskeleton plasma membrane plasma membrane endomembrane system

Pathways

Signal Transduction Signaling by Rho GTPases MAPK family signaling cascades MAPK6/MAPK4 signaling RHO GTPase cycle CDC42 GTPase cycle RHOQ GTPase cycle Signaling by Rho GTPases, Miro GTPases and RHOBTB3 Glucocorticoid Receptor Pathway Nuclear Receptors Meta-Pathway

via MyGene.info

Gene · Ensembl

CDC42 effector protein 3

Symbol: CDC42EP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:37,641,882-37,738,468
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 4708
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/10602
genomic end: 37965611
genomic start: 37869032
chromosome: human chromosome 2
cytogenetic location: 2p22.2
expressed in: myometrium

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

4 sections

Contents

Interactions
References
External links
Further reading

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.

Excerpted from Wikipedia’s “CDC42EP3” article, available under the CC BY-SA 4.0 licence.