CDC42EP3

Also known as BORG2, CEP3, UB1, CDC42 effector protein 3

Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

Gene data

CDC42EP3

Name: CDC42 effector protein 3
Type: protein-coding
Aliases: BORG2, CEP3, UB1

This gene encodes a member of a small family of guanosine triphosphate (GTP) metabolizing proteins that contain a CRIB (Cdc42, Rac interactive binding) domain. Members of this family of proteins act as effectors of CDC42 function. The encoded protein is involved in actin cytoskeleton re-organization during cell shape changes, including pseudopodia formation. A pseudogene of this gene is found on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012].

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Gene · Ensembl

CDC42 effector protein 3

Symbol: CDC42EP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:37,641,882-37,738,468
Strand: Reverse (−)
Assembly: GRCh38

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via Ensembl · EMBL-EBI

Wikidata facts

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HomoloGene ID: 4708
exact match: identifiers.org/ncbigene/10602
genomic end: 37965611
genomic start: 37869032
cytogenetic location: 2p22.2

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Cdc42 effector protein 3 is a protein that in humans is encoded by the CDC42EP3 gene.

CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. This protein can interact with CDC42, as well as with the ras homolog gene family, member Q (ARHQ/TC10). Expression of this protein in fibroblasts has been shown to induce pseudopodia formation.