CDKAL1
Sign in to saveAlso known as CDK5 regulatory subunit associated protein 1 like 1
CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of this have not been fully determined. CDKAL1 is known to code for CDK5, a regulatory subunit-associated protein 1. This protein CDK5 regulatory subunit-associated protein 1 is found broadly across tissue types including neuronal tissues and pancreatic beta cells. CDKAL1 is suspected to be involved in the CDK5/p35 pathway, in which p35 is the activator for CDK5 which regulates several neuronal functions.
In the Vinony graph
Vinony's link graph records 7 inbound references to CDKAL1, and connects out to PubMed, single-nucleotide polymorphism and human chromosome 6.
It is catalogued under the topic Genes on human chromosome 6.
Vinony links it to 7 Wikipedia language editions.
Gene data
CDKAL1- Name
- CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
- Type
- protein-coding
- Position
- 20,534,442–21,232,855 (+)
- Ensembl
- ENSG00000145996
- RefSeq RNA
- NM_017774.3, XM_011514718.1, XM_011514719.3, XM_017010986.2, XM_024446481.2
- RefSeq protein
- NP_060244.2, XP_011513020.1, XP_011513021.1, XP_016866475.1, XP_024302249.1
The protein encoded by this gene is a member of the methylthiotransferase family. The function of this gene is not known. Genome-wide association studies have linked single nucleotide polymorphisms in an intron of this gene with susceptibilty to type 2 diabetes. [provided by RefSeq, May 2010].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
CDKAL1 threonylcarbamoyladenosine tRNA methylthiotransferase
- Symbol
- CDKAL1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:20,534,442-21,232,855
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
Show 8 more facts
- HomoloGene ID
- 9830
- genetic association
- Crohn's disease
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/54901
- genomic end
- 21232635
- genomic start
- 20534688
- chromosome
- human chromosome 6
- cytogenetic location
- 6p22.3
via Wikidata · CC0
~2 min read
Encyclopedic overview
6 sectionsContents
- Structure and function
- Clinical significance
- Animal studies
- References
- External links
- Further reading
CDKAL1 (Cdk5 regulatory associated protein 1-like 1) is a gene in the methylthiotransferase family. The complete physiological function and implications of this have not been fully determined. CDKAL1 is known to code for CDK5, a regulatory subunit-associated protein 1. This protein CDK5 regulatory subunit-associated protein 1 is found broadly across tissue types including neuronal tissues and pancreatic beta cells. CDKAL1 is suspected to be involved in the CDK5/p35 pathway, in which p35 is the activator for CDK5 which regulates several neuronal functions.
== Structure and function ==
Excerpted from Wikipedia’s “CDKAL1” article, available under the CC BY-SA 4.0 licence.