CHMP3

Also known as NEDF, VPS24, CGI-149, charged multivesicular body protein 3

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

Gene data

CHMP3

Name: charged multivesicular body protein 3
Type: protein-coding
Position: 86,503,430–86,563,507 (−)
Aliases: CGI-149, NEDF, VPS24
Ensembl: ENSG00000115561
RefSeq RNA: NM_001005753.3, NM_001193517.2, NM_016079.4, NR_036454.2
RefSeq protein: NP_001005753.1, NP_001180446.1, NP_057163.1

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010].

Pathways

Endocytosis - Homo sapiens (human)Necroptosis - Homo sapiens (human)HIV Life Cycle Budding and maturation of HIV virion Late Phase of HIV Life Cycle HIV Infection Macroautophagy Cell Cycle Disease Disease

via MyGene.info

Gene · Ensembl

charged multivesicular body protein 3

Symbol: CHMP3
Biotype: Protein coding
Organism: Homo sapiens
Location: 2:86,502,688-86,563,507
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Protein VPS24 PDB 2gd5.png

Show 5 more facts

HomoloGene ID: 6368
exact match: identifiers.org/ncbigene/51652
genomic start: 86503430
genomic end: 86948245
cytogenetic location: 2p11.2

Sources (3)

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Article

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Contents

Function
Interactions
References
Further reading

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

== Function == This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.