CHMP3

Also known as NEDF, VPS24, CGI-149, charged multivesicular body protein 3

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

Gene data

CHMP3

Name: charged multivesicular body protein 3
Type: protein-coding
Position: 86,503,430–86,563,507 (−)
Aliases: CGI-149, NEDF, VPS24
Ensembl: ENSG00000115561
RefSeq RNA: NM_001005753.3, NM_001193517.2, NM_016079.4, NR_036454.2
RefSeq protein: NP_001005753.1, NP_001180446.1, NP_057163.1

This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010].

Gene Ontology

Biological process

plasma membrane repair

Article

4 sections

Contents

Function
Interactions
References
Further reading

Charged multivesicular body protein 3 is a protein that in humans is encoded by the VPS24 gene.

== Function == This gene encodes a protein that acts in the sorting of transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants encoding different isoforms.