ESCRT complex
Sign in to saveAlso known as GO:0036452, endosomal sorting complex required for transport, ESCRT, endosomal sorting complexes required for transport
The endosomal sorting complexes required for transport (ESCRT) proteins are part of a pathway inside cells that helps sort and move other proteins. One of their main jobs is to form structures called multivesicular bodies (MVBs) which help sending of certain proteins, especially ones tagged for removal, to compartments in the cell called lysosomes where they get broken down.
Research
2,301 papers- The ESCRT pathway.Developmental cell · 2011
- ALIX- and ESCRT-III-dependent sorting of tetraspanins to exosomes.The Journal of cell biology · 2020
- The many functions of ESCRTs.Nature reviews. Molecular cell biology · 2020
- Triggered recruitment of ESCRT machinery promotes endolysosomal repair.Science (New York, N.Y.) · 2018
- The ESCRT-III complex contributes to macromitophagy in yeast.Traffic (Copenhagen, Denmark) · 2021
via PubMed
~26 min read
Article
11 sectionsContents
- ESCRT complexes and accessory proteins
- ESCRT-0
- ESCRT-I
- ESCRT-II
- ESCRT-III
- Vps4-Vta1
- Structure and function of Bro1 in endosomal sorting
- Multivesicular body biogenesis and cargo shuttling
- Membrane abscission
- Viral budding
- References
The endosomal sorting complexes required for transport (ESCRT) proteins are part of a pathway inside cells that helps sort and move other proteins. One of their main jobs is to form structures called multivesicular bodies (MVBs) which help sending of certain proteins, especially ones tagged for removal, to compartments in the cell called lysosomes where they get broken down.
The ESCRT system is made up of five separate cytosolic, peripheral membrane protein complexes, known as ESCRT-0, ESCRT-I, ESCRT-II, ESCRT-III and Vps4. Together with a number of accessory proteins, these ESCRT complexes enable a unique mode of membrane remodeling that results in membranes budding away from the cytoplasm. These ESCRT components have been isolated and studied in a number of organisms including yeast and humans.