Structure via PubChem · Public domain (PubChem)
cianopramine
Sign in to saveCianopramine (INN; development code Ro 11-2465; also known as 3-cyanoimipramine) is a tricyclic antidepressant related to imipramine that acts as a serotonin reuptake inhibitor and weak serotonin receptor antagonist. It was investigated for the treatment of depression but was never marketed.
Chemical data
- Formula
- C20H23N3
- Molecular weight
- 305.4 g/mol
- IUPAC name
- 11-[3-(dimethylamino)propyl]-5,6-dihydrobenzo[b][1]benzazepine-2-carbonitrile
- SMILES
- CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)C#N
- InChIKey
- LQXYCDLHSKICDY-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 30.3 Ų
- H-bond donors
- 0
- H-bond acceptors
- 3
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
62 papers- A controlled trial of amitriptyline and cianopramine in major depression.Clinical therapeutics · 1985
- Cianopramine and amitriptyline in the treatment of depressed patients--a placebo-controlled study.Psychopharmacology · 1985
- Effect of cianopramine, a tricyclic antidepressant, on platelet serotonin uptake and peripheral adrenergic function.Clinical pharmacology and therapeutics · 1984
- [Computer-assisted static and dynamic pupillometry for the characterization of tricyclic antidepressive agent, cianopramine].Arzneimittel-Forschung · 1988
- Acute and chronic treatment with 5-HT reuptake inhibitors differentially modulate emotional responses in anxiety models in rodents.Psychopharmacology · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 305.189
Show 3 more facts
- chemical formula
- C₂₀H₂₃N₃
- canonical SMILES
- CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)C#N
- subject has role
- serotonin antagonist
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Cianopramine (INN; development code Ro 11-2465; also known as 3-cyanoimipramine) is a tricyclic antidepressant related to imipramine that acts as a serotonin reuptake inhibitor and weak serotonin receptor antagonist. It was investigated for the treatment of depression but was never marketed.
== See also == Clomipramine Cyanodothiepin Cyamemazine
Excerpted from Wikipedia’s “cianopramine” article, available under the CC BY-SA 4.0 licence.