Structure via PubChem · Public domain (PubChem)
سیکلهزونید
Sign in to saveAlso known as RPR-251526, (R)-11b,16a,17,21-Tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with cyclohexanecarboxaldehyde 21-isobutyrate
Ciclesonide, sold under the brand name Omnaris among others, is a glucocorticoid used to treat asthma and allergic rhinitis.
Chemical data
- Formula
- C32H44O7
- Molecular weight
- 540.7 g/mol
- IUPAC name
- [2-[(1S,2S,4R,6R,8S,9S,11S,12S,13R)-6-cyclohexyl-11-hydroxy-9,13-dimethyl-16-oxo-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 2-methylpropanoate
- SMILES
- CC(C)C(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)O[C@H](O2)C6CCCCC6
- InChIKey
- LUKZNWIVRBCLON-GXOBDPJESA-N
- XLogP
- 5.3
- Polar surface area
- 99.1 Ų
- H-bond donors
- 1
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2006
- Admin. routes
- topical
- Indications
- allergic rhinitis, seasonal allergic rhinitis, Airway obstruction, Nasal congestion
via ChEMBL · EBI
Research
518 papers- Ciclesonide.2006
- Inhaled ciclesonide for outpatients with COVID-19: A meta-analysis.Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi · 2022
- Ciclesonide.Drugs · 2004
- Ciclesonide nasal spray: in allergic rhinitis.Drugs · 2008
- Ciclesonide: a novel inhaled corticosteroid.Expert opinion on investigational drugs · 2004
via PubMed
Wikidata facts
- Has part
- carbon
- Mass
- 540.309
- Has use
- medication
Show 6 more facts
- World Health Organisation international non-proprietary name
- ciklesonid
- chemical formula
- C₃₂H₄₄O₇
- defined daily dose
- 0.2
- canonical SMILES
- CC(C)C(=O)OCC(=O)C12C(CC3C1(CC(C4C3CCC5=CC(=O)C=CC45C)O)C)OC(O2)C6CCCCC6
- isomeric SMILES
- CC(C)C(=O)OCC(=O)[C@@]12[C@@H](C[C@@H]3[C@@]1(C[C@@H]([C@H]4[C@H]3CCC5=CC(=O)C=C[C@]45C)O)C)O[C@H](O2)C6CCCCC6
- Commons category
- Ciclesonide
Sources (6)
via Wikidata · CC0