Structure via PubChem · Public domain (PubChem)
cilazapril
Sign in to saveAlso known as Inhibace®, Ro 31-2848006, Vascace®, cilazapril anhydrous, Cilazapril anhydrous, Cilazaprilum
Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.
Chemical data
- Formula
- C22H31N3O5
- Molecular weight
- 417.5 g/mol
- IUPAC name
- (4S,7S)-7-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]azaniumyl]-6-oxo-1,2,3,4,7,8,9,10-octahydropyridazino[1,2-a]diazepine-4-carboxylate
- SMILES
- CCOC(=O)[C@H](CCC1=CC=CC=C1)[NH2+][C@H]2CCCN3CCC[C@H](N3C2=O)C(=O)[O-]
- InChIKey
- HHHKFGXWKKUNCY-FHWLQOOXSA-N
- XLogP
- 1.2
- Polar surface area
- 107 Ų
- H-bond donors
- 1
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Research
650 papers- Cilazapril. A review.Drugs · 1991
- Clinical pharmacology of cilazapril.The American journal of medicine · 1989
- Clinical pharmacology of cilazapril.Drugs · 1991
- Cilazapril. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in cardiovascular disease.Drugs · 1991
- Cilazapril-induced SIADH.Journal of the American Geriatrics Society · 2001
via PubMed
~1 min read
Encyclopedic overview
3 sectionsContents
- Chemistry
- Brand names
- References
{{chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 460036705 | ImageFile = Cilazapril structure.svg | ImageClass = skin-invert-image | ImageFile_Ref = | ImageSize = 222 | ImageName = Kekulé, stereo, skeletal formula of cilazapril ((1S,9S)-9-[(2S)-2-yl]amin,-1-carbox) | PIN = (1S,9S)-9-{[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid
|Section1 =
Excerpted from Wikipedia’s “cilazapril” article, available under the CC BY-SA 4.0 licence.