COPA

Name

coat protein complex I subunit alpha

Type

protein-coding

Position

160,288,594–160,343,566 (−)

Aliases

AIAISD, AIAISD1, AILJK, HEP-COP, alpha-COP

Ensembl

ENSG00000122218

RefSeq RNA

NM_001098398.2, NM_004371.4

RefSeq protein

NP_001091868.1, NP_004362.2

In eukaryotic cells, protein transport between the endoplasmic reticulum and Golgi compartments is mediated in part by non-clathrin-coated vesicular coat proteins (COPs). Seven coat proteins have been identified, and they represent subunits of a complex known as coatomer. The subunits are designated alpha-COP, beta-COP, beta-prime-COP, gamma-COP, delta-COP, epsilon-COP, and zeta-COP. The alpha-COP, encoded by COPA, shares high sequence similarity with RET1P, the alpha subunit of the coatomer complex in yeast. Also, the N-terminal 25 amino acids of alpha-COP encode the bioactive peptide, xenin, which stimulates exocrine pancreatic secretion and may act as a gastrointestinal hormone. Alternative splicing results in multiple splice forms encoding distinct isoforms. [provided by RefSeq, Jul 2008].

via MyGene.info

Wikidata facts

Image

The structure of the COPI coat linkage I - Coatomer subunit alpha (2) 5NZT.png

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